..:: Prospektywne badanie oparte na obserwacji chorych na schizofrenię w Polsce - wstępne wyniki dotyczące skuteczności i tolerancji leczenia po 6 miesiącach 469 ::..
| Prospektywne badanie oparte na obserwacji chorych na schizofrenię w Polsce - wstępne wyniki dotyczące skuteczności i tolerancji leczenia po 6 miesiącach 469 |
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Joanna Meder, Grażyna Dębowska, Joanna Lis, Aleksander Araszkiewicz, Katarzyna Sierosławska, Andrea Kolesaric, Tamas Treuer
Prospektywne badanie oparte na obserwacji chorych na schizofrenię w Polsce - wstępne wyniki dotyczące skuteczności i tolerancji leczenia po 6 miesiącach 469
Summary Aim: To compare the effectiveness and tolerability of olanzapine and other antipsychotic treatments (6 months after enrollment) in Polish patients with schizophrenia participating in the IC-SOHO (the Intercontinental Schizophrenia Outpatient Health Outcomes) study. Method: IC-SOHO is a 3-year, global, prospective, observational study examining health outcomes in outpatients with schizophrenia undergoing treatment with antipsychotics. Patients were offered enrollment by a psychiatrist if they initiated or changed antipsychotic medication for the treatment of schizophrenia. The study was designed to provide two patient cohorts of approximately equal size: patients who initiated or switched to olanzapine, and patients who initiated or switched to non-olanzapine antipsychotic therapy. Mean changes in positive, negative, cognitive, depressive and overall symptoms from baseline to 6 months, as measured using the CGI scale, were assessed. The incidence of extrapyramidal symptoms and sexual dysfunctions and weight changes were compared. Results: Out of 7648 patients participating in the IC-SOHO study, 626 patients were enrolled in Poland. After 3 and 6 months of treatment, significantly greater improvement in overall symptoms measured using the CGI scale was observed in patients with olanzapine than in those with other antipsychotics. Response rate at 6 months was significantly higher in the olanzapine group than in the non-olanzapine group. Incidence of extrapyramidal symptoms and sexual dysfunctions was lower in olanzapine group. Conclusions: After 6 months, olanzapine-treated patients showed greater improvement of clinical status compared with other antipsychotic treatment. Olanzapine treatment was more beneficial for patients; comparing to other antipsychotic treatment less extrapyramidal symptoms and sexual dysfunctions were observed. |
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Lista artykułów w numerze :
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| Numer: |
3 |
| Tytuł: |
PSYCHIATRIA POLSKA 3/2004 |
| Wydany: |
2004-06-01 |
| Lista wszystkich numerów: |
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