Piotr Gałecki

Pro-and antioxidant processes in schizophrenics with tardive dyskinesia

Summary

Central nervous system diseases are connected with the production of an increased amount of reactive oxygen species. Decreased antioxidant activity is considered as one of the reasons of tardive dyskinesia (TD) in schizophrenic patients in a prolonged neuroleptic treatment course. Aim: The evaluation of superoxide dismutase, catalase, glutathione peroxidase activity as well as lipid peroxidation by TBARS saturation in blood paleted in schizophrenic patients with or without tardive dyskinesia symptoms.

Material and methods: 84 paranoid schizophrenic patients took part in the study, 40 of them with TD symptoms. The groups were comparative in clinical and demographic terms. Indication of TBARS in blood paleted was performed by Placed and others' method. GSH-Px activity was indicated by Little and O‛Brien method. CAT activity was indicated according to the Beers and others' method. CuZnSOD activity in blood paleted was indicated by Mirsa and Fridovich method.

Results: CuZnSOD activity in schizophrenic patients without TD is 820.23 and accordingly 710.75 U/g in TD symptoms patients and it is statistical essential. TBARS for patients with TD is 1.06 and accordingly without TD is 0.92 µmol/109, the difference is statistically essential. For groups with and without TD CAT activity is 19.87 and 17.93Ub/g accordingly and GSH-Px is 32.30 and 30.48 U/g.

Conclusions: Schizophrenic patients with TD symptoms have lower CuZnSOD activity and higher concentration of TBARS in the paleted blood than patients without TD. CAT activity is higher in patients with TD symptoms. CuZnSOD activity and concentration of TBARS are in correlation with age in both groups under study.